A facile synthesis of 1-oxo-pyrrolo[2,1-a]isoquinolines

[Display omitted] •A novel approach towards polysubstituted pyrrolo[2,1-a]isoquinolines was developed.•Migration of the aryl group accompanies the target molecule formation.•Functional groups of the products can be used for further modification. The facile synthesis of 1-oxo-pyrrolo[2,1-a]isoquinoli...

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Bibliographic Details
Published inTetrahedron letters Vol. 58; no. 9; pp. 877 - 879
Main Authors Voskressensky, Leonid G., Borisova, Tatiana N., Matveeva, Maria D., Khrustalev, Viktor N., Titov, Alexander A., Aksenov, Alexander V., Dyachenko, Svetlana V., Varlamov, Alexey V.
Format Journal Article
LanguageEnglish
Published OXFORD Elsevier Ltd 01.03.2017
Elsevier
Subjects
Activated alkynes
Chemistry
Chemistry, Organic
Lamellarin
Physical Sciences
Pyrrolo[2,1-a]isoquinolines
Science & Technology
Pyrrolo[2,1-a]isoquinolines
Activated alkynes
Lamellarin
PORTULACA-OLERACEA
ISOQUINOLINES
CASCADE
DERIVATIVES
ALKALOIDS
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Summary:[Display omitted] •A novel approach towards polysubstituted pyrrolo[2,1-a]isoquinolines was developed.•Migration of the aryl group accompanies the target molecule formation.•Functional groups of the products can be used for further modification. The facile synthesis of 1-oxo-pyrrolo[2,1-a]isoquinolines from the reaction of 1-aroyl-3,4-dihydroisoquinolines and symmetrical alkynes in toluene is described. The novel compounds contain functional groups that are suitable for further modification.
ISSN:0040-4039
1873-3581
DOI:10.1016/j.tetlet.2017.01.061