l-Ascorbic acid in organic synthesis: a facile synthesis of 4-(butenolide-5-methylidenyl)-1,4-dihydropyridines

An efficient synthesis of 4-(butenolide-5-methylidenyl)-1,4-dihydropyridines has been achieved via a three-component reaction of β-keto esters or ketones, ammonium acetate and vinylic aldehydes from ascorbic acid in the presence of tetrabutylammonium hydrogen sulfate in ethylene glycol.

Saved in:
Bibliographic Details
Published inTetrahedron letters Vol. 48; no. 7; pp. 1187 - 1189
Main Authors Bisht, Surendra S., Dwivedi, Namrata, Tripathi, Rama P.
Format Journal Article
LanguageEnglish
Published OXFORD Elsevier Ltd 12.02.2007
Elsevier
Subjects
1,4-Dihydropyridines
4-(Butenolide-5-methylidenyl)-1,4-dihydropyridines
Ammonium acetate
Chemistry
Chemistry, Organic
l-Ascorbic acid
Physical Sciences
Science & Technology
Tetrabutylammonium hydrogen sulfate
Tetrabutylammonium hydrogen sulfate
Ammonium acetate
4-(Butenolide-5-methylidenyl)-1,4-dihydropyridines
l-Ascorbic acid
1,4-Dihydropyridines
MILD
tetrabutylammonium hydrogen sulfate
L-ascorbic acid
ONE-POT SYNTHESIS
HANTZSCH 1,4-DIHYDROPYRIDINES
EFFICIENT SYNTHESIS
CHEMISTRY
1,4-dihydropyridines
4-(butenolide-5-methylidenyl)-1,4-dihydropyridines
DERIVATIVES
AROMATIZATION
ammonium acetate
Online AccessGet full text

Cover

More Information
Summary:An efficient synthesis of 4-(butenolide-5-methylidenyl)-1,4-dihydropyridines has been achieved via a three-component reaction of β-keto esters or ketones, ammonium acetate and vinylic aldehydes from ascorbic acid in the presence of tetrabutylammonium hydrogen sulfate in ethylene glycol.
ISSN:0040-4039
1873-3581
DOI:10.1016/j.tetlet.2006.12.067