A new and direct approach to functionalized biaryl α-ketophosphonic acids via aqueous Suzuki coupling on solid support
A new method for the synthesis of functionalized biaryl α-ketophosphonic acids has been developed. The key step involves the use of sodium bromobenzoyl phosphonates to react with polymer-bound boronic acids via microwave-assisted aqueous Suzuki coupling. This approach provides rapid access to a wide...
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Published in | Tetrahedron letters Vol. 47; no. 1; pp. 19 - 22 |
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Main Authors | , , , , , , , , |
Format | Journal Article |
Language | English |
Published |
OXFORD
Elsevier Ltd
02.01.2006
Elsevier |
Subjects | |
Online Access | Get full text |
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Summary: | A new method for the synthesis of functionalized biaryl α-ketophosphonic acids has been developed. The key step involves the use of sodium bromobenzoyl phosphonates to react with polymer-bound boronic acids via microwave-assisted aqueous Suzuki coupling. This approach provides rapid access to a wide range of diverse biaryl analogues containing an α-ketophosphonic acid moiety. |
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ISSN: | 0040-4039 1873-3581 |
DOI: | 10.1016/j.tetlet.2005.10.122 |