Highly sensitive wearable glucose sensor systems based on functionalized single-wall carbon nanotubes with glucose oxidase-nafion composites

• Published in: Applied surface science Vol. 470; pp. 13 - 18
• Main Authors: Kang, Byeong-Cheol, Park, Ban-Suk, Ha, Tae-Jun
• Format: Journal Article
• Language: English
• Published: Elsevier B.V 15.03.2019
• Subjects: Glucose oxidase; Nafion; Single-wall carbon nanotubes; Smartphone; Surface-functionalization; Wearable glucose sensor system; Wearable glucose sensor system; Glucose oxidase; Single-wall carbon nanotubes; Nafion; Smartphone; Surface-functionalization
• ISSN: 0169-4332; 1873-5584
• DOI: 10.1016/j.apsusc.2018.11.101

[Display omitted] •We demonstrate highly sensitive wearable SWCNT-based glucose sensor systems upon smartphone.•Surface-functionalization with GOD-nafion composites enhanced the sensing performance of glucose sensors.•We investigate the sensing mechanism of glucose sensors by analyzing the oxidation-reduction reaction.•Wearable glucose sensors fabricated by all-solution process can open up a new route for health-care diagnosis system. Since the first demonstration of a biosensor was reported, big efforts have been reported to improve the sensing performance of bioelectronics by investigating the material compositions, device configurations, process optimization, and system integration. In this paper, we demonstrate highly sensitive wearable carbon-based glucose sensors fabricated by all-solution process at low temperature. Solution-processed single-wall carbon nanotube (SWCNT) random networks as a sensing platform were surface-functionalized with the enzyme glucose oxidase (GOD)-nafion composites, which can detect glucose down to 50 μM with a response time of less than 5 s. We also investigate the sensing mechanism of SWCNT-based glucose sensors through molecular oxidation-reduction reactions in GOD with glucose. Material characterization using X-ray photoelectron spectroscopy and Raman spectra measurements proves the existence of SWCNT random networks with chemical incorporation through a surface-functionalization process. We believe that the proposed wearable SWCNT-based glucose sensors fabricated by all-solution process can open up a promising route to realize a low-cost and high performance health-care diagnosis system integrated with the user’s smartphone for diabetic patients.