Synthesis of bridged 1,4-diazepane derivatives via Schmidt reactions

A series of bridged 1,4-diazepanes (i.e., diazabicyclo[ n.3.2]alkanes, n = 3–5) selectively protected at one of the nitrogen atoms was prepared, for possible application in drug design, via Schmidt rearrangement of the corresponding ketones.

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Bibliographic Details
Published inTetrahedron letters Vol. 51; no. 13; pp. 1790 - 1792
Main Authors Mityuk, Andrey P., Denisenko, Aleksandr V., Dacenko, Oleksandr P., Grygorenko, Oleksandr O., Mykhailiuk, Pavel K., Volochnyuk, Dmitriy M., Tolmachev, Andrey A.
Format Journal Article
LanguageEnglish
Published OXFORD Elsevier Ltd 31.03.2010
Elsevier
Subjects
Chemistry
Chemistry, Organic
Physical Sciences
Science & Technology
CHEMISTRY
DRUG DISCOVERY
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Summary:A series of bridged 1,4-diazepanes (i.e., diazabicyclo[ n.3.2]alkanes, n = 3–5) selectively protected at one of the nitrogen atoms was prepared, for possible application in drug design, via Schmidt rearrangement of the corresponding ketones.
ISSN:0040-4039
1873-3581
DOI:10.1016/j.tetlet.2010.01.121