Two new prenylated phenols from endogenous fungus Pestalotiopsis vaccinii of mangrove plant Kandelia candel (L.) Druce

• Published in: Phytochemistry letters Vol. 12; pp. 59 - 62
• Main Authors: Wang, Junfeng, Wei, Xiaoyi, Qin, Xiaochu, Chen, Hao, Lin, Xiuping, Zhang, Tianyu, Yang, Xianwen, Liao, Shengrong, Yang, Bin, Liu, Juan, Zhou, Xuefeng, Tu, Zhengchao, Liu, Yonghong
• Format: Journal Article
• Language: English
• Published: Elsevier Ltd 01.06.2015
• Subjects: COX-2 inhibitory activity; Pestalotiopsis vaccinii; Structure elucidation; Structure elucidation; Pestalotiopsis vaccinii; COX-2 inhibitory activity
• ISSN: 1874-3900; 1876-7486
• DOI: 10.1016/j.phytol.2015.02.013

•Two new prenylated phenols, 1 and 2, were isolated from the fungus Pestalotiopsis vaccinii.•Their structures were determined based on 1D, 2D NMR techniques and CD data.•The new compound vaccinol I (2) showed potent COX-2 inhibitory activity with IC50 value of 16.8μM. Two new prenylated phenols vaccinol H (1) and vaccinol I (2), together with three known phenols derivatives 3–5, one glyceride derivative 6, and ergosterol 7 were isolated from endogenous Pestalotiopsis vaccinii (cgmcc3.9199) of mangrove plant Kandelia candel (L.) Druce (Rhizophoraceae). The new structures of 1 and 2 were determined by spectroscopic analyses and circular dichroism (CD) spectra. Most of the isolated compounds (2–6) were tested for their antiviral (EV71), cytotoxic, anti-tuberculosis, and anti-inflammatory effects. Among these compounds, compound 2 exhibited potent COX-2 inhibitory activity with an IC50 value of 16.8μM.