Conjugate base catalysed one-pot synthesis of pyrazoles from β-formyl enamides

A novel one-pot synthesis of pyrazoles has been accomplished by the reaction of β-formyl enamides with hydroxylamine hydrochloride catalysed by potassium dihydrogenphosphate in acid medium.

Saved in:
Bibliographic Details
Published inTetrahedron letters Vol. 47; no. 1; pp. 43 - 46
Main Authors Saikia, Anil, Barthakur, Madan G., Borthakur, Moyurima, Saikia, Chandan J., Bora, Utpal, Boruah, Romesh C.
Format Journal Article
LanguageEnglish
Published OXFORD Elsevier Ltd 02.01.2006
Elsevier
Subjects
Chemistry
Chemistry, Organic
Conjugate base
Hydroxylamine hydrochloride
Physical Sciences
Pyrazole
Science & Technology
β-Formyl enamide
β-Formyl enamide
Hydroxylamine hydrochloride
Conjugate base
Pyrazole
hydroxylamine hydrochloride
COX-2
STEROIDAL INHIBITORS
pyrazole
IDENTIFICATION
CELECOXIB
HUMAN CYTOCHROME P450(17-ALPHA)
OXIMES
ANNELATED PYRIDINES
CYCLOOXYGENASE-2 INHIBITORS
beta-formyl enamide
conjugate base
DERIVATIVES
SELECTIVITY
Online AccessGet full text

Cover

More Information
Summary:A novel one-pot synthesis of pyrazoles has been accomplished by the reaction of β-formyl enamides with hydroxylamine hydrochloride catalysed by potassium dihydrogenphosphate in acid medium.
ISSN:0040-4039
1873-3581
DOI:10.1016/j.tetlet.2005.10.145