Thiosemicarbazides, 1,3,4 thiadiazole Schiff base derivatives of transition metal complexes as antimicrobial agents

• Published in: Inorganic chemistry communications Vol. 160; p. 111856
• Main Authors: Pervaiz, Muhammad, Quratulain, Rimsha, Ejaz, Anam, Shahin, Musarat, Saeed, Zohaib, Nasir, Shagufta, Rashad Mahmood Khan, Rana, Ashraf, Adnan, Ullah, Sami, Younas, Umer
• Format: Journal Article
• Language: English
• Published: Elsevier B.V 01.02.2024
• Subjects: 1,3,4 thiadiazole; Antimicrobial agents; Metal chelates; Schiff bases; Thiosemicarbazides; Schiff bases; Antimicrobial agents; Metal chelates; 1,3,4 thiadiazole; Thiosemicarbazides
• ISSN: 1387-7003; 1879-0259
• DOI: 10.1016/j.inoche.2023.111856

[Display omitted] •Mono and binuclear stable metal chelates with bio-potent novel Schiff base ligands of N, O and S donors are engrossed.•Thiosemicarbazides and 1,3,4 thiadizole have been advanced for copious biological investigations.•Chelation, structure diversity and stability of metal complexes prompt in reinforcement the antimicrobial potency of metal complexes.•Assessment executed for biological potential of synthesized Schiff base ligands and complexes. Metal complexes of Schiff base ligands (exhibit imine -C = N- functional group) derived from thiosemicarbazide and 1,3,4 thiadiazole have attracted the attention of researchers on account of excellent broad range applications in a variety of fields from material sciences to biological sciences. Broad range of factors such that involvement of N, S, and O donor atoms, chelating property, chemical adaptability, minimum toxicity owing to -N-C = S linkage, structure topologies and diversity, polydentate ligands, aromaticity, extended conjugations in 1,3,4 thiadiazole and stability accommodate pharmacological potential. Widespread organic precursors (aromatic aldehyde and primary amine) have been used for the development of novel Schiff base ligands and metal complexes. Metal chelates inclusive of d-block transition metals and non-transition metals with broad distinct features have also been synthesized and evaluated via various classical and advanced spectral and analytical techniques. This review encompasses the synthesis, spectral studies and investigations that have been reported for Thiosemicarbazides, 1,3,4 thiadiazole Schiff base derivatives of transition metal complexes followed by evaluation of wide variety of biological applications. This review summarizes advancements in research over the last 15 years (2007–2022).