Synthesis of 8-( S)-methoxy-11-desmethyl laulimalide: a novel laulimalide analogue

• Published in: Tetrahedron letters Vol. 46; no. 6; pp. 923 - 926
• Main Authors: Gallagher, Brian M., Zhao, Hongjuan, Pesant, Marc, Fang, Francis G.
• Format: Journal Article
• Language: English
• Published: OXFORD Elsevier Ltd 07.02.2005; Elsevier
• Subjects: Analogue; Chemistry; Chemistry, Organic; Laulimalide; Physical Sciences; Science & Technology; Analogue; Laulimalide; RESISTANT; laulimalide; CYTOTOXIC MACROLIDES; AGENT LAULIMALIDE; TAXOID SITE; BIOLOGICAL EVALUATION; analogue; ABSOLUTE-CONFIGURATIONS; TUBULIN; (-)-LAULIMALIDE; PELORUSIDE; PACLITAXEL

[Display omitted] A strategy is outlined which enables preparation of novel laulimalide analogues at C.8 and C.11. A representative analogue, 8-( S)-methoxy-11-desmethyl laulimalide, was synthesized via this route.