Synthesis of 8-( S)-methoxy-11-desmethyl laulimalide: a novel laulimalide analogue

[Display omitted] A strategy is outlined which enables preparation of novel laulimalide analogues at C.8 and C.11. A representative analogue, 8-( S)-methoxy-11-desmethyl laulimalide, was synthesized via this route.

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Bibliographic Details
Published inTetrahedron letters Vol. 46; no. 6; pp. 923 - 926
Main Authors Gallagher, Brian M., Zhao, Hongjuan, Pesant, Marc, Fang, Francis G.
Format Journal Article
LanguageEnglish
Published OXFORD Elsevier Ltd 07.02.2005
Elsevier
Subjects
Analogue
Chemistry
Chemistry, Organic
Laulimalide
Physical Sciences
Science & Technology
Analogue
Laulimalide
RESISTANT
laulimalide
CYTOTOXIC MACROLIDES
AGENT LAULIMALIDE
TAXOID SITE
BIOLOGICAL EVALUATION
analogue
ABSOLUTE-CONFIGURATIONS
TUBULIN
(-)-LAULIMALIDE
PELORUSIDE
PACLITAXEL
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Summary:[Display omitted] A strategy is outlined which enables preparation of novel laulimalide analogues at C.8 and C.11. A representative analogue, 8-( S)-methoxy-11-desmethyl laulimalide, was synthesized via this route.
ISSN:0040-4039
1873-3581
DOI:10.1016/j.tetlet.2004.12.056