Overview of the fracture healing cascade

Fracture healing is a dynamic process being governed by a variety of cellular elements and stimulating agents. Our knowledge in understanding the molecular and cellular processes occurring in healing fractures has vastly expanded as a result of the advances made in all aspects of medicine. The abili...

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Bibliographic Details
Published inInjury Vol. 36; no. 3; pp. S5 - S7
Main Author Phillips, A.M.
Format Journal Article
LanguageEnglish
Published Netherlands Elsevier Ltd 01.11.2005
Subjects
Animals
Bone healing
Bone Regeneration - physiology
Callus formation
Cytokines - metabolism
Fracture Healing - physiology
Fractures, Bone - physiopathology
Growth factors
Growth Substances - physiology
Humans
Mesenchymal stem cells
Rats
Callus formation
Bone healing
Growth factors
Mesenchymal stem cells
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Summary:Fracture healing is a dynamic process being governed by a variety of cellular elements and stimulating agents. Our knowledge in understanding the molecular and cellular processes occurring in healing fractures has vastly expanded as a result of the advances made in all aspects of medicine. The ability to manipulate mesenchymal stem cells and to deliver locally growth factors in order to create new bone has led to a proliferation of research papers. The purpose of this article is to provide a brief overview of the current level of understanding of the physiological processes regulating the healing of fractures.
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ISSN:0020-1383
1879-0267
DOI:10.1016/j.injury.2005.07.027