Epstein-Barr Virus Seroprevalence and Primary Infection at the University Hospital Luigi Vanvitelli of Naples from 2007 to 2017

• Published in: Intervirology Vol. 62; no. 1; pp. 15 - 22
• Main Authors: Franci, Gianluigi, Crudele, Valeria, Della Rocca, Maria Teresa, Melardo, Colombina, Chianese, Annalisa, Finamore, Emiliana, Bencivenga, Francesco, Astorri, Roberta, Vitiello, Mariateresa, Galdiero, Emilia, Galdiero, Massimiliano
• Format: Journal Article
• Language: English
• Published: Basel, Switzerland 01.01.2019
• Subjects: Research Article; IgG; Epstein-Barr virus; EBV nuclear antigen; Primary infection; IgM
• ISSN: 0300-5526; 1423-0100
• DOI: 10.1159/000496828

Epstein-Barr virus (EBV) is a common herpesvirus that may cause asymptomatic infection or various diseases, such as mononucleosis, lymphoproliferative disorders and several cancers. Our objective was to estimate the prevalence of EBV among patients hospitalized in “Luigi Vanvitelli” University Hospital in the last 10 years. Our results showed that EBV seroprevalence in our geographical area was 65%. Seroprevalence increased gradually with age with no significant difference between females (49.42%) and males (50.58%). The seropositivity for primary infection was higher in patients about 5 years old, while seropositivity for past infection was predominant in patients of about 35 years old. These results underline that children in our country are still exposed to EBV. The development and the deeper use of an EBV vaccine in the early years of life could represent the solution for this infection.