Small cell lung cancer with paraneoplastic lipase production

Kulchitsky cells represent the cells of origin of small cell lung cancer (SCLC). They display an antigenic makeup characteristic of both the neural crest and epithelium and have been shown to secrete both polypeptide hormones and enzymes. The coexistence of two or more (concomitant or sequential) pa...

Full description

Saved in:
Bibliographic Details
Published inSouthern medical journal (Birmingham, Ala.) Vol. 103; no. 8; p. 819
Main Authors Dasanu, Constantin A, Clark, 3rd, Bernard A, Lahiri, Bimalin, Ichim, Thomas E, Alexandrescu, Doru T
Format Journal Article
LanguageEnglish
Published United States 01.08.2010
Subjects
Fatal Outcome
Humans
Inappropriate ADH Syndrome - etiology
Lipase - blood
Lung Neoplasms - enzymology
Male
Middle Aged
Paraneoplastic Syndromes - complications
Paraneoplastic Syndromes - enzymology
Small Cell Lung Carcinoma - enzymology
Online AccessGet more information

Cover

More Information
Summary:Kulchitsky cells represent the cells of origin of small cell lung cancer (SCLC). They display an antigenic makeup characteristic of both the neural crest and epithelium and have been shown to secrete both polypeptide hormones and enzymes. The coexistence of two or more (concomitant or sequential) paraneoplastic endocrine syndromes is possible with SCLC, and paraneoplastic amylase production has also been described with this malignancy. We present here the first patient with an extensive stage SCLC, exhibiting a marked paraneoplastic lipase production and a syndrome of inappropriate antidiuretic hormone (SIADH) secretion. In our patient, the paraneoplastic hyperlipasemia paralleled both the initial SCLC response to chemotherapy and its subsequent clinicoradiological relapse.
ISSN:1541-8243
DOI:10.1097/SMJ.0b013e3181e6369e