Hollow fiber liquid phase microextraction combined with liquid chromatography-tandem mass spectrometry for the analysis of emerging contaminants in water samples

• Published in: Microchemical journal Vol. 140; pp. 87 - 95
• Main Authors: Salvatierra-stamp, Vilma, Muñiz-Valencia, Roberto, Jurado, Jose M., Ceballos-Magaña, Silvia G.
• Format: Journal Article
• Language: English
• Published: Elsevier B.V 01.07.2018
• Subjects: Emerging contaminants; Hollow fiber liquid phase microextraction; Liquid chromatography; Water samples; Liquid chromatography; Hollow fiber liquid phase microextraction; Emerging contaminants; Water samples
• ISSN: 0026-265X; 1095-9149
• DOI: 10.1016/j.microc.2018.04.012

This document describes a microextraction technique using a porous polypropylene hollow fiber for the analysis of 27 emerging contaminants (ECs) in water samples by means of liquid chromatography-tandem mass spectrometry. The ECs under study were aniline, metformin, acetaminophen, carbazole, aldicarb, caffeine, thiabendazole, carbaryl, ibuprofen, atrazine, carbofuran, 2,4-dichlorophenoxyacetic acid, ametryn, bisphenol A, diuron, carbamazepine, methyl parathion, disulfoton, triclosan, diazinon, tebuconazole, malathion, chlorpyrifos, hydrocortisone, temephos, glibenclamide and 4 nitrophenol. The chromatographic separation was achieved in 13 min. The analyte detection was carried out using a triple quadrupole mass spectrometer, allowing the detection of a precursor ion and its fragmentation (product ions). The two-phase hollow fiber liquid phase microextraction conditions were optimized considering the parameters: organic solvent selection, sample pH, fiber length, sample volume, extraction time, stirring rate, sample temperature and salting-out effect. The developed method was validated. Detection and quantification limits were in the range of 1.09 to 98.15 ng L−1 and 2.13 to 126.50 ng L−1, respectively. The range of enrichment factor was from 6 to 4177. The method was successfully applied to water samples from various sources such as effluents from sewage treatment plants and surface water. [Display omitted] •A LC-MS/MS method for determining 27 emerging contaminants in water was development.•Experimental Design and response surface method was done to optimize sample treatment.•Sample treatment with HF-LPME achieves an enrichment factor range from 6 to 4177.•The method was validated as a quantitative screening method.•The method was applied to the other environmental water samples with positive results.