Antibacterial and non-hemolytic cationic polyurethanes with N-carboxymethyl-N,N,N-triethylammonium groups for bacteremia-control in biomedical-using materials

• Published in: Materials today communications Vol. 22; p. 100708
• Main Authors: Palencia, Manuel, Lerma, Tulio A., Arrieta, Álvaro A.
• Format: Journal Article
• Language: English
• Published: Elsevier Ltd 01.03.2020
• Subjects: Antibacterial surface; Bacteremia; Mannitol; Polyurethane; Quaternary ammonium; Quaternary ammonium; Polyurethane; Bacteremia; Antibacterial surface; Mannitol
• ISSN: 2352-4928; 2352-4928
• DOI: 10.1016/j.mtcomm.2019.100708

[Display omitted] •Bacteremia is one of the main problems associated in intrahospital medical procedures.•Making of polyurethanes based on quaternary ammonium groups with bio- and blood-compatibility.•To developed new cationic polyurethanes by free solvent tri-component reactions.•Obtaining of novel antibacterial and non-hemolytic materials based on polyurethanes. The aim of this work was to develop new antibacterial and non-hemolytic materials based on cationic polyurethanes with quaternary ammonium units. Thus, bacteremia control in intrahospital environments can be carried out by active interface on biomedical devices. Tricomponent synthesis was used based on di-isocyanate, a polyol of low molecular weight and N-carboxymethyl-N,N,N-triethylammonium chloride (CMtEACl). Several materials were obtained and characterized by different spectroscopic and thermal techniques, in addition, antibacterial and non-hemolytic properties were evaluated in order to evaluate the effectivity in the microbial control at surface level and compatibility with tissue by the evaluation of compatibility with blood. Manuscript is directed toward the following subjects: (1) ceramic, metallic, polymeric, and composite materials for medical applications, in particular, though antibacterial properties are a designed feature defined from synthesis stage, and (2) hemolytic properties of these cationic polyurethanes based on CMtEACl have not previously reported. Results shown that cationic these materials possess high antimicrobial activity in function of CMtEACl mole fraction and low hemolytic activity being a promissory alternative for the development of new coating for biomedical materials with capacity to inactivate microorganisms in medical procedures with high risk of bacteremia.