Integrated LaFeO3/rGO nanocomposite for the sensitive electrochemical detection of antibiotic drug metronidazole in urine and milk samples

• Published in: Applied surface science Vol. 635; p. 157672
• Main Authors: Pandiyan, Rajaram, Vinothkumar, Venkatachalam, Chen, Shen-Ming, Sangili, Arumugam, Kim, Tae Hyun
• Format: Journal Article
• Language: English
• Published: Elsevier B.V 30.10.2023
• Subjects: Antibiotic drug; Electrochemical method; Perovskites; Rare-earth metal ferrites; Real-time analysis; Perovskites; Rare-earth metal ferrites; Real-time analysis; Electrochemical method; Antibiotic drug
• ISSN: 0169-4332; 1873-5584
• DOI: 10.1016/j.apsusc.2023.157672

Integration of LFO/rGO nanocomposite for the electrochemical detection of MTZ in human urine and milk samples. [Display omitted] •LFO/rGO nanocomposite was synthesized through a facile sonochemical approach.•LFO/rGO/GCE had excellent electrocatalytic activity for MTZ.•The modified sensor exhibited a wide linear range and a low limit of detection.•The sensor showed outstanding performance in the analysis of urine and milk samples. Metronidazole (MTZ) is a nitroimidazole antibiotic commonly used to treat bacterial infections, but its residues in food products may pose teratogenic, mutagenic, and carcinogenic risks to human health. Hence, monitoring MTZ in food and human samples is essential. In this study, we developed a glassy carbon electrode (GCE) modified with lanthanum ferrite (LFO) integrated with reduced graphene oxide (rGO) nanocomposite for the electrochemical detection of MTZ. The engineered nanocomposite was prepared by the sonochemical treatment and then systematically characterized using X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR), Raman spectroscopy, X-ray photoelectron spectroscopy (XPS), field emission scanning electron microscopy (FESEM), and transmission electron microscopy (TEM) techniques. The modified LFO/rGO/GCE exhibits excellent electrochemical performance, which is mainly owing to the high surface areas, conductivity, and synergistic effects of LFO and rGO. Using the DPV method, the LFO/rGO/GCE sensor showed a wide linear range of 0.2–1221 µM and a low LOD of 0.048 µM for MTZ detection. The modified sensor selectivity was confirmed with biological species and metal compounds. In addition, the developed sensor demonstrated good stability, reproducibility, and repeatability toward MTZ. Satisfactory recoveries were obtained for MTZ detection in human urine and milk samples using the fabricated LFO/rGO/GCE sensor.