Eclipse of viral DNA infectivity in SPO1-infected Bacillus subtilis

The DNA of bacteriophage SPO1, which is normally infective for competent Bacillus subtilis, is modified after phage infection so as to render it noninfective. Infective DNA reappears in phage-infected cells shortly after the onset of viral DNA replication. This eclipse of infectivity is correlated w...

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Published inVirology (New York, N.Y.) Vol. 50; no. 1; pp. 267 - 272
Main Author Levner, Mark H.
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 01.10.1972
Subjects
Adenine - metabolism
Bacillus subtilis
Bacteriophages - metabolism
Carbon Isotopes
Centrifugation, Density Gradient
DNA Replication
DNA, Bacterial
DNA, Single-Stranded
DNA, Viral - biosynthesis
DNA, Viral - isolation & purification
Hydrogen-Ion Concentration
Lysogeny
Nucleic Acid Denaturation
Nucleic Acid Hybridization
Time Factors
Transformation, Genetic
Tritium
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Summary:The DNA of bacteriophage SPO1, which is normally infective for competent Bacillus subtilis, is modified after phage infection so as to render it noninfective. Infective DNA reappears in phage-infected cells shortly after the onset of viral DNA replication. This eclipse of infectivity is correlated with the appearance of single-strand breaks in the infecting viral DNA, which are repaired to some extent by by the time of reappearance of infectivity.
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ISSN:0042-6822
1096-0341
DOI:10.1016/0042-6822(72)90369-8