CuI catalyzed sulfamidation of arylboronic acid using TsNBr2 at room temperature

[Display omitted] •New source for sulfamidation of boronic acid.•New pathway for CN bond formation.•Expeditious process-Short reaction time.•Excellent yield of Aryl sulfonamide.•Works well with a wide range of boronic acids. An expeditious protocol for amidation arylboronic acid has been developed u...

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Bibliographic Details
Published inTetrahedron letters Vol. 58; no. 52; pp. 4855 - 4858
Main Authors Loukrakpam, Dineshwori Chanu, Phukan, Prodeep
Format Journal Article
LanguageEnglish
Published OXFORD Elsevier Ltd 27.12.2017
Elsevier
Subjects
Arylboronic acid
Arylsulfonamide
Chemistry
Chemistry, Organic
CuI
Physical Sciences
Science & Technology
TsNBr2
TsNBr2
CuI
Arylboronic acid
Arylsulfonamide
C-N
METAL-FREE PROTOCOL
PROTEASE INHIBITORS
SULFONAMIDE DERIVATIVES
BORONIC ACIDS
BROMAMINE-T
ANTICONVULSANT ACTIVITY
ARYL HALIDES
FACILE GENERATION
Cul
N-ARYLATION
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Summary:[Display omitted] •New source for sulfamidation of boronic acid.•New pathway for CN bond formation.•Expeditious process-Short reaction time.•Excellent yield of Aryl sulfonamide.•Works well with a wide range of boronic acids. An expeditious protocol for amidation arylboronic acid has been developed using TsNBr2 as the nitrogen source in presence of a CuI as catalyst. Various arylboronic acids could be transformed into corresponding N-arylsulfonamide derivatives within a very short time using CuI as catalyst in presence of DBU at room temperature.
ISSN:0040-4039
1873-3581
DOI:10.1016/j.tetlet.2017.11.033