Synthesis and analytical evaluation by voltammetric studies of some new indole-3-propionamide derivatives

• Published in: Farmaco (Società chimica italiana : 1989) Vol. 56; no. 11; pp. 835 - 840
• Main Authors: Süzen, Sibel, Ateş-Alagöz, Zeynep, Demircigil, B.Tolga, Özkan, Sibel A
• Format: Journal Article
• Language: English
• Published: Lausanne Elsevier SAS 01.11.2001; Elsevier Science
• Subjects: Amides - chemical synthesis; Amides - chemistry; Analysis; Analytical chemistry; Chemistry; Electrochemical methods; Electrochemistry; Exact sciences and technology; General and physical chemistry; Hydrogen-Ion Concentration; Indole-3-propionic derivatives; Indoles - chemical synthesis; Indoles - chemistry; Kinetics and mechanism of reactions; Magnetic Resonance Spectroscopy; Mass Spectrometry; Synthesis; Voltammetry; Indole-3-propionic derivatives; Voltammetry; Synthesis; Analysis; Chemical analysis; Nitrogen heterocycle; Electrochemical method; Calibration; Carbon; Electrodes; Cyclic voltammetry; Medium effect; Tertiary amine; Bicyclic compound; pH; Carboxamide; Aromatic compound; Chemical synthesis; Quantitative analysis; Glassy state
• ISSN: 0014-827X; 1879-0569
• DOI: 10.1016/S0014-827X(01)01150-8

Some biologically important and melatonin-related indole-3-propionamide derivatives were synthesized. The compounds synthesized were analyzed and characterized first by NMR and mass spectrometry and then investigated by analytical voltammetric techniques. Based on this study a simple, rapid and sensitive voltammetric method was developed for the determination of the indole derivatives that are readily oxidized at the carbon-based electrodes. The oxidative behavior of the indole derivatives was studied as a function of pH at a glassy carbon electrode. The characteristics of the corresponding electrode reaction were discussed.