A highly selective and ratiometric molecular probe for cyanide sensing based on a phenothiazine-hemicyanine dye

A new ratiometric fluorescent probe was designed based on hemicyanine moiety as a cyanide reaction site for nucleophilic addition. The titration experiment for CN- showed this probe exhibits high selectivity, a low limit of detection to 20 nM and quick response for CN- sensing. At the addition of CN...

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Bibliographic Details
Published inJournal of luminescence Vol. 201; pp. 474 - 478
Main Authors Zhao, Hong-Wei, Wu, Gang, Sun, Xue-Yi, Chao, Jian-Bin, Li, YingQi, Jiang, Lydia, Han, Hui
Format Journal Article
LanguageEnglish
Published Elsevier B.V 01.09.2018
Subjects
Cyanide
Fluorescent probe
Hemicyanine
Phenothiazine
Ratiometric
Cyanide
Hemicyanine
Ratiometric
Fluorescent probe
Phenothiazine
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Summary:A new ratiometric fluorescent probe was designed based on hemicyanine moiety as a cyanide reaction site for nucleophilic addition. The titration experiment for CN- showed this probe exhibits high selectivity, a low limit of detection to 20 nM and quick response for CN- sensing. At the addition of CN-, the colour of the solution changed from purple to colourless, accompanied by an increase in the fluorescence intensity. The sensing behavior was investigated by changes of UV–vis spectra, HRMS and 1H NMR. Furthermore a HepG2 cell imaging experiment demonstrated the application prospect for tracing cyanide anions in biological systems. [Display omitted] •A new ratiometric fluorescent probe was developed for CN- detecting.•The probe showed excellent sensitivity with a low limit of detection to 20 nM.•The probe displayed high selectivity for CN-.•A cell imaging experiment demonstrated the prospect for tracing cyanide anions.
ISSN:0022-2313
1872-7883
DOI:10.1016/j.jlumin.2018.05.021