Recent advances in the synthesis of fused heterocycles with new skeletons via alkyne cyclization

[Display omitted] •Recent developments on the synthesis of fused-heterocycles is presented.•Au-catalyzed or NaH-promoted alkyne cyclization is reported.•A new methodology for the synthesis of pyridine-fused compounds is also presented. An account of our most recent developments on the synthesis of v...

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Bibliographic Details
Published inTetrahedron letters Vol. 61; no. 24; p. 151994
Main Author Balci, Metin
Format Journal Article
LanguageEnglish
Published Elsevier Ltd 11.06.2020
Subjects
Alkyne
Allene
AuCl3 as catalyst
DFT calculations
Fused-heterocycles
Fused-heterocycles
Allene
AuCl3 as catalyst
DFT calculations
Alkyne
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Summary:[Display omitted] •Recent developments on the synthesis of fused-heterocycles is presented.•Au-catalyzed or NaH-promoted alkyne cyclization is reported.•A new methodology for the synthesis of pyridine-fused compounds is also presented. An account of our most recent developments on the synthesis of various fused heterocycles via alkyne cyclization is presented. The synthetic strategy involves N- or O-propargylation of heteroaromatic or aromatic compounds followed by intramolecular gold-catalyzed or NaH-promoted intramolecular cyclization reactions. This synthetic strategy represents a reasonable methodology for the construction of hitherto unknown skeletons.
ISSN:0040-4039
1873-3581
DOI:10.1016/j.tetlet.2020.151994