Lack of Association Between the ACE2 G8790A Gene Variation and Risk for Basal Cell Carcinoma

Background/Aim: The G8790A (rs2285666) functional polymorphism of the angiotensin-converting enzyme 2 (ACE2) gene influences alternative mRNA splicing and quantitatively affects the enzyme's production. Specifically, the presence of the A allele has been associated with higher ACE2 plasma level...

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Published inAnticancer research Vol. 41; no. 8; pp. 4021 - 4026
Main Authors Gintoni, Iphigenia, Vassiliou, Stavros, Avgoustidis, Dimitris, Adamopoulou, Mary, Zavras, Nikolaos, Papakosta, Veronica, Vlachakis, Dimitris, Yapijakis, Christos
Format Journal Article
LanguageEnglish
Published Athens International Institute of Anticancer Research 01.08.2021
Subjects
ACE2
Alternative splicing
Angiotensin
Angiotensin-converting enzyme 2
Basal cell carcinoma
Deoxyribonucleic acid
DNA
Electrophoresis
Enzymes
Gel electrophoresis
Gene polymorphism
Genotyping
mRNA
Pathogenesis
Peptidyl-dipeptidase A
Plasma levels
Polymorphism
Skin cancer
Statistical methods
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Summary:Background/Aim: The G8790A (rs2285666) functional polymorphism of the angiotensin-converting enzyme 2 (ACE2) gene influences alternative mRNA splicing and quantitatively affects the enzyme's production. Specifically, the presence of the A allele has been associated with higher ACE2 plasma levels. In this study, we investigated the possible association of the functional polymorphism ACE2-G8790A with the pathogenesis of basal cell carcinoma (BCC). Patients and Methods: A total of 190 DNA samples were studied, including 91 BCC patients and 99 controls of Greek origin. Molecular genotyping for the ACE2 G8790A polymorphism was carried out by PCR amplification, followed by AluI enzyme digestion and agarose gel electrophoresis of the DNA fragments. Results: The allelic and genotypic frequencies presented no statistical difference between the patient and the control group. Conclusion: There is no association between the ACE2 G8790A polymorphism and pathogenesis of BCC.
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ISSN:0250-7005
1791-7530
DOI:10.21873/anticanres.15201