Daphnodorin dimers from Edgeworthia chrysantha with α-glucosidase inhibitory activity

• Published in: Phytochemistry letters Vol. 3; no. 4; pp. 242 - 247
• Main Authors: Zhou, Tong, Zhang, Shu-wei, Liu, Shan-shan, Cong, Hai-jian, Xuan, Li-jiang
• Format: Journal Article
• Language: English
• Published: Elsevier Ltd 17.12.2010
• Subjects: Condensed tannins; Daphnodorin dimer; Edgeworthia chrysantha; Thymelaeaceae; α-Glucosidase inhibitors; α-Glucosidase inhibitors; Edgeworthia chrysantha; Thymelaeaceae; Daphnodorin dimer; Condensed tannins
• ISSN: 1874-3900; 1876-7486
• DOI: 10.1016/j.phytol.2010.10.001

Four daphnodorin dimers, named edgechrins A–D, were isolated from the stems and twigs of Edgeworthia chrysantha along with four daphnodorin monomers, daphnodorin A, B, C and I. Their inhibitory activities of α-glucosidase were evaluated. [Display omitted] ▶ Four daphnodorin dimers were isolated from Edgeworthia chrysantha. ▶ Structures of them were established by spectroscopic methods. ▶ Daphnodorin dimers showed α-glucosidase inhibitory activities. Four daphnodorin dimers named herein as edgechrins A–D ( 1– 4) were isolated from the stems and twigs of Edgeworthia chrysantha Lindl. along with four known compounds identified as daphnodorin A ( 5), B ( 6), C ( 7) and I ( 8). Their structures were established by spectroscopic methods, including IR, HR-MS, and 1D- and 2D NMR. All of these compounds showed potent in vitro α-glucosidase inhibitory activity with IC 50 values in the range of 0.4–20 μM.