Isolation and synthesis of a novel β-carboline guanidine derivative tiruchanduramine from the Indian ascidian Synoicum macroglossum

The isolation and synthesis of a novel β-carboline guanidine alkaloid, tiruchanduramine, a potent α-glucosidase inhibitor from the Indian ascidian Synoicum macroglossum has been achieved. The isolation and synthesis of the racemic form of a novel β-carboline guanidine alkaloid, tiruchanduramine, a p...

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Published inTetrahedron letters Vol. 46; no. 33; pp. 5475 - 5478
Main Authors Ravinder, K., Vijender Reddy, A., Krishnaiah, P., Ramesh, P., Ramakrishna, S., Laatsch, H., Venkateswarlu, Y.
Format Journal Article
LanguageEnglish
Published OXFORD Elsevier Ltd 15.08.2005
Elsevier
Subjects
Ascidian
Chemistry
Chemistry, Organic
Physical Sciences
Science & Technology
Synoicum macroglossum
Tiruchanduramine
α-Glucosidase inhibitor
β-carboline
α-Glucosidase inhibitor
Synoicum macroglossum
Tiruchanduramine
β-carboline
Ascidian
ACID
alpha-glucosidase inhibitor
ESTERS
tiruchanduramine
beta-carboline
ascidian
MARINE NATURAL-PRODUCTS
ALKALOIDS
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Summary:The isolation and synthesis of a novel β-carboline guanidine alkaloid, tiruchanduramine, a potent α-glucosidase inhibitor from the Indian ascidian Synoicum macroglossum has been achieved. The isolation and synthesis of the racemic form of a novel β-carboline guanidine alkaloid, tiruchanduramine, a potent α-glucosidase inhibitor from the Indian ascidian, Synoicum macroglossum has been achieved.
ISSN:0040-4039
1873-3581
DOI:10.1016/j.tetlet.2005.06.060