2,6-Dichloroquinone chlorimide and 7,7,8,8-tetracyanoquinodimethane reagents for the spectrophotometric determination of salbutamol in pure and dosage forms

• Published in: Journal of pharmaceutical and biomedical analysis Vol. 28; no. 6; pp. 1127 - 1133
• Main Authors: Mohamed, G.G., Khalil, Shaban M., Zayed, M.A., El-Shall, M.Abd El-Hamid
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier B.V 15.06.2002; Elsevier Science
• Subjects: 2,6-Dichloroquinone chlorimide (DCQ); 7,7,8,8-Tetracyanoquinodimethane (TCNQ); Adrenergic beta-Agonists - analysis; Albuterol - analysis; Analysis; Benzoquinones; Biological and medical sciences; Dosage Forms; General pharmacology; Imines; Indicators and Reagents; Medical sciences; Nitriles; Pharmaceutical preparations; Pharmaceutical Preparations - analysis; Pharmacology. Drug treatments; Salbutamol; Spectrophotometric; Spectrophotometry - methods; Pharmaceutical preparations; Spectrophotometric; Salbutamol; 2,6-Dichloroquinone chlorimide (DCQ); 7,7,8,8-Tetracyanoquinodimethane (TCNQ); Agonist; Analysis method; Analytical reagent; Bronchodilator; Dosage form; β2-Adrenergic receptor; β-Adrenergic receptor agonist; Raw materials; Spectrophotometry; Electron acceptor; Quantitative analysis
• ISSN: 0731-7085; 1873-264X
• DOI: 10.1016/S0731-7085(01)00718-X

A simple, rapid and sensitive spectrophotometric method for the determination of sulbutamol in pure form and in different pharmaceutical preparations has been developed. The charge transfer (CT) reaction between salbutamol as electron donor and 2,6-dichloroquinone chlorimide (DCQ) and 7,7,8,8-tetracyanoquinodimethane (TCNQ) as a π-electron acceptor have been spectrophotometrically studied. The optimum experimental conditions for these CT reactions have been studied carefully. Beer's law is obeyed over the concentration range of 1.0–30.0 μg ml −1 and 2.0–20.0 μg ml −1 for salbutamol using DCQ and TCNQ, respectively. For more accurate results, Ringbom optimum concentration range is calculated and found to be 10.0 to 30.0 and 8.0 to 20 μg ml −1 for salbutamol using DCQ and TCNQ, respectively. The Sandell sensitivity is found to be 0.011 and 0.010 g cm −2 for salbutamol using DCQ and TCNQ, respectively, which indicate the high sensitivity of the proposed methods. Relative standard deviations (R.S.D.) of 0.27 to 0.68% and 0.20 to 1.40% ( n=5) were obtained for five replicates of salbutamol using DCQ and TCNQ, respectively. The results obtained by the two reagents are comparable with those obtained by British pharmacopoeia assay for the determination of salbutamol in raw materials and in pharmaceutical preparations.