Choice of the optimal synthetic approach for the polypeptide ligands of prostatic specific membrane antigen preparation

[Display omitted] Two alternative synthetic schemes involving solid-phase peptide synthesis steps for the preparation of prostatic specific membrane antigen ligands based on Glu-Urea-Lys with peptide fragments in the linker structure are compared. In the first approach, the amino acid key intermedia...

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Published inMendeleev communications Vol. 33; no. 4; pp. 472 - 475
Main Authors Zyk, Nikolay Yu, Petrov, Stanislav A., Zavertkina, Maria V., Uspenskaya, Anastasia A., Krasnikov, Pavel A., Dashkova, Natalia S., Beloglazkina, Elena K., Majouga, Alexander G., Zyk, Nikolay V., Machulkin, Aleksei E.
Format Journal Article
LanguageEnglish
Published Elsevier B.V 01.07.2023
Subjects
anticancer drugs
prostate cancer
prostatic specific membrane antigen
solid-phase peptide synthesis
targeted delivery
solid-phase peptide synthesis
targeted delivery
prostate cancer
prostatic specific membrane antigen
anticancer drugs
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Summary:[Display omitted] Two alternative synthetic schemes involving solid-phase peptide synthesis steps for the preparation of prostatic specific membrane antigen ligands based on Glu-Urea-Lys with peptide fragments in the linker structure are compared. In the first approach, the amino acid key intermediate is attached to the 2-CTC resin by the carboxy group while in the second approach, by the amino one. The preference for each approach is dependent on the particular target molecule
ISSN:0959-9436
DOI:10.1016/j.mencom.2023.06.010