Frontal Assessment Battery and Cerebrospinal Fluid Tap Test in Idiopathic Normal-Pressure Hydrocephalus

Our aim in this study was to assess whether the frontal assessment battery (FAB) could contribute to the differential diagnosis of cerebrospinal fluid tap test (CSFTT) responders and nonresponders with the hypothesis that CSFTT nonresponders had greater frontal lobe dysfunction. We also explored whe...

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Bibliographic Details
Published inEuropean neurology Vol. 77; no. 5-6; p. 327
Main Authors Ko, Pan-Woo, Lee, Ho-Won, Kang, Kyunghun
Format Journal Article
LanguageEnglish
Published Switzerland 01.01.2017
Subjects
Aged
Female
Frontal Lobe - pathology
Frontal Lobe - physiopathology
Humans
Hydrocephalus, Normal Pressure - complications
Hydrocephalus, Normal Pressure - diagnosis
Male
Middle Aged
Neuropsychological Tests
Spinal Puncture
Normal-pressure hydrocephalus
Frontal assessment battery
Markers
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Summary:Our aim in this study was to assess whether the frontal assessment battery (FAB) could contribute to the differential diagnosis of cerebrospinal fluid tap test (CSFTT) responders and nonresponders with the hypothesis that CSFTT nonresponders had greater frontal lobe dysfunction. We also explored whether a relationship exists between FAB scores and gait disturbance in idiopathic normal-pressure hydrocephalus (INPH) patients. INPH subjects were selected in a consecutive order from a prospectively enrolled INPH registry. Fifty-one INPH patients constituted the final sample for analysis. Logistic regression analysis using the FAB score as independent variable showed a significant influence of the FAB on the differential diagnosis of CSFTT responders and nonresponders (p = 0.025; OR 1.186; 95% CI 1.022-1.377). The FAB scores were negatively correlated with the Timed Up and Go test score (r = -0.382; p = 0.007), 10-meter walking test score (r = -0.351; p = 0.014), Gait Status Scale score (r = -0.382; p = 0.007), and INPH Grading Scale gait score (r = -0.370; p = 0.009). Our findings may indicate a possibility for considering FAB scores in patients with ventriculomegaly as potential cognitive markers for the prediction of CSFTT response. Association between gait function and FAB scores suggests the involvement of similar circuits producing gait symptom and frontal lobe functions in INPH.
ISSN:1421-9913
DOI:10.1159/000472712