Selective Hofmann alkylation of aromatic-aliphatic diamines in the presence of carbon dioxide

[Display omitted] Selective Hofmann alkylation at arylamino group in carbon dioxide medium was demonstrated on model diamines containing aliphatic and aromatic primary amino groups, namely, 2-H2NC6H4CH2NH2, 3-H2NC6H4CH(Me)NH2, and 4-H2NC6H4CH2CH2NH2. Depending on the spatial factors, di- or trialkyl...

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Published inMendeleev communications Vol. 29; no. 4; pp. 438 - 440
Main Authors Balybin, Alexei G., Panov, Yuri M., Erkhova, Ludmila V., Lemenovskii, Dmitry A., Krut’ko, Dmitry P.
Format Journal Article
LanguageEnglish
Published Elsevier B.V 01.07.2019
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Summary:[Display omitted] Selective Hofmann alkylation at arylamino group in carbon dioxide medium was demonstrated on model diamines containing aliphatic and aromatic primary amino groups, namely, 2-H2NC6H4CH2NH2, 3-H2NC6H4CH(Me)NH2, and 4-H2NC6H4CH2CH2NH2. Depending on the spatial factors, di- or trialkylarylammonium derivatives are selectively formed in amide solvents (DMF, DMA) without additional base.
ISSN:0959-9436
DOI:10.1016/j.mencom.2019.07.028