Nutritional supplementation of hop rho iso-alpha acids, berberine, vitamin D3 , and vitamin K1 produces a favorable bone biomarker profile supporting healthy bone metabolism in postmenopausal women with metabolic syndrome

• Published in: Nutrition research (New York, N.Y.) Vol. 31; no. 5; pp. 347 - 355
• Main Authors: Lamb, Joseph J, Holick, Michael F, Lerman, Robert H, Konda, Veera R, Minich, Deanna M, Desai, Anuradha, Chen, Tai C, Austin, Melissa, Kornberg, Jacob, Chang, Jyh-Lurn, Hsi, Alex, Bland, Jeffrey S, Tripp, Matthew L
• Format: Journal Article
• Language: English
• Published: New York, NY Elsevier 01.05.2011
• Subjects: Anti-Inflammatory Agents - pharmacology; Anti-Inflammatory Agents - therapeutic use; Berberine - pharmacology; Berberine - therapeutic use; Biological and medical sciences; Biomarkers - blood; Bone and Bones - drug effects; Bone and Bones - metabolism; Cholecalciferol - pharmacology; Cholecalciferol - therapeutic use; Collagen Type I - blood; Dietary Supplements; Feeding. Feeding behavior; Female; Fundamental and applied biological sciences. Psychology; Gastroenterology and Hepatology; Humans; Humulus; Insulin-Like Growth Factor I - metabolism; Metabolic Syndrome - blood; Metabolic Syndrome - complications; Middle Aged; Osteocalcin - blood; Osteoporosis, Postmenopausal - blood; Osteoporosis, Postmenopausal - etiology; Osteoporosis, Postmenopausal - prevention & control; Phytotherapy; Plant Extracts - pharmacology; Plant Extracts - therapeutic use; Single-Blind Method; Vertebrates: anatomy and physiology, studies on body, several organs or systems; Vitamin D - analogs & derivatives; Vitamin D - blood; Vitamin K 1 - pharmacology; Vitamin K 1 - therapeutic use; Vitamins - pharmacology; Vitamins - therapeutic use; apolipoprotein; IGF-I; RANKL; Randomized clinical trial; insulin-like growth factor I; PTH; cTx; high-density lipoprotein; P1NP; OPG; cross-linked N-telopeptides of type I procollagen; Postmenopausal women; HDL; Kinase modulation; OC; receptor activator nuclear factor κB ligand; Humulus lupulus; 25(OH)D; BMI; apo; parathyroid hormone; Dietary supplement; 25-hydroxyvitamin D; cross-linked C-telopeptides of type I collagen; Mediterranean diet; body mass index; Bone turnover; RIAA; NTx; amino-terminal propeptide of type I collagen; Phytochemicals; osteocalcin; osteoprotegerin; rho iso-alpha acids; Endocrinopathy; Vitamin; Biological marker; Cardiovascular disease; Supplemented diet; Metabolic syndrome; Osteoarticular system; Modulation; Turnover; Postmenopause; Clinical trial; Female; Human; Osteocalcin; Metabolic diseases; Metabolism; Feeding; Retinol; Vertebrata; Mammalia; Bone
• ISSN: 0271-5317; 1879-0739
• DOI: 10.1016/j.nutres.2011.03.016

Abstract Metabolic syndrome poses additional risk for postmenopausal women who are already at risk for osteoporosis. We hypothesized that a nutritional supplement containing anti-inflammatory phytochemicals and essential bone nutrients would produce a favorable bone biomarker profile in postmenopausal women with metabolic syndrome. In this 14-week, randomized trial, 51 women were instructed to consume a modified Mediterranean-style, low-glycemic-load diet and to engage in aerobic exercise. Those in the intervention arm (n = 25) additionally received 200 mg hop rho iso-alpha acids, 100 mg berberine sulfate trihydrate, 500 IU vitamin D3 , and 500 μ g vitamin K1 twice daily. Forty-five women completed the study. Baseline nutrient intake did not differ between arms. Compared with baseline, the intervention arm exhibited an approximate 25% mean decrease ( P < .001) in serum osteocalcin (indicative of bone turnover), whereas the placebo arm exhibited a 21% increase ( P = .003). Serum 25-hydroxyvitamin D increased 23% ( P = .001) in the intervention arm and decreased 12% ( P = .03) in the placebo arm. The between-arm differences for osteocalcin and 25-hydroxyvitamin D were statistically significant. Serum insulin-like growth factor I was statistically increased in both arms, but the between-arm differences were not statistically significant. Subanalysis showed that among those in the highest tertile of baseline insulin-like growth factor I, the intervention arm exhibited a significant increase in amino-terminal propeptide of type I collagen, whereas the placebo arm showed a significant decrease at 14 weeks. Treatment with rho iso-alpha acids, berberine, vitamin D3 , and vitamin K1 produced a more favorable bone biomarker profile indicative of healthy bone metabolism in postmenopausal women with metabolic syndrome.