Synthesis of uracil–coumarin conjugates as potential inhibitors of virus replication

[Display omitted] A series of 1-[(bromophenoxy)alkyl]uracil–coumarin conjugates has been obtained through the preparation of starting 1-[(bromophenoxy)alkyl]uracil derivatives, followed by their treatment with 7-(ω-bromoalkoxy)-4-methyl-2H-chromen-2-ones. Two of the synthesized uracil–coumarin conju...

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Published inMendeleev communications Vol. 29; no. 6; pp. 638 - 639
Main Authors Paramonova, Maria P., Ozerov, Alexander A., Chizhov, Alexander O., Snoeck, Robert, Andrei, Graciela, Khandazhinskaya, Anastasia L., Novikov, Mikhail S.
Format Journal Article
LanguageEnglish
Published Elsevier B.V 01.11.2019
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Summary:[Display omitted] A series of 1-[(bromophenoxy)alkyl]uracil–coumarin conjugates has been obtained through the preparation of starting 1-[(bromophenoxy)alkyl]uracil derivatives, followed by their treatment with 7-(ω-bromoalkoxy)-4-methyl-2H-chromen-2-ones. Two of the synthesized uracil–coumarin conjugates demonstrated a pronounced inhibitory activity against HCMV and VZV replication in vitro.
ISSN:0959-9436
DOI:10.1016/j.mencom.2019.11.010