The metabolism of 6-methylaminopurine in Salmonella typhimurium

6-Methylaminopurine-free base is efficiently utilized by growing cultures of various mutants of Salmonella typhimurium for the biosynthesis of polynucleotide purines. In the “purineless” mutant Ade-11 it competes favorably with adenine, guanine and hypoxanthine in this regard, and in two specific ad...

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Published inBiochimica et biophysica acta. Specialized section on nucleic acids and related subjects Vol. 68; pp. 519 - 525
Main Authors Duggan, D.E., Weigert, M.G., Grieb, W.E., Titus, E.O.
Format Journal Article
LanguageEnglish
Published Elsevier B.V 1963
Subjects
MAP
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Summary:6-Methylaminopurine-free base is efficiently utilized by growing cultures of various mutants of Salmonella typhimurium for the biosynthesis of polynucleotide purines. In the “purineless” mutant Ade-11 it competes favorably with adenine, guanine and hypoxanthine in this regard, and in two specific adenine-dependent mutants effects a unique growth increment beyond that attainable on adenine. It is suggested that 6-methylaminopurine-free base enters the normal polynucleotide synthetic pathway via direct conversion to a 5′-nucleotide, and demethylamination to IMP.
ISSN:0926-6550
1878-2256
DOI:10.1016/0926-6550(63)90476-6