Two new anthraquinone dimers from the stem bark of Pentas schimperi (Rubiaceae)
•Isolation and structural elucidation of two new anthraquinone dimers.•Cytotoxicity of schimperiquinone B (2) against human cancer cell line BGC-823.•First report of cleomiscosin A from the genus Pentas. Two new anthraquinone dimers, schimperiquinones A (1) and B (2), together with the known 2-hydro...
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Published in | Phytochemistry letters Vol. 8; pp. 55 - 58 |
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Main Authors | , , , , , , , |
Format | Journal Article |
Language | English |
Published |
Elsevier Ltd
01.05.2014
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Subjects | |
Online Access | Get full text |
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Summary: | •Isolation and structural elucidation of two new anthraquinone dimers.•Cytotoxicity of schimperiquinone B (2) against human cancer cell line BGC-823.•First report of cleomiscosin A from the genus Pentas.
Two new anthraquinone dimers, schimperiquinones A (1) and B (2), together with the known 2-hydroxymethylanthraquinone (3), cleomiscosin A (4), oleanolic acid (5) and sitosterol 3-O-β-d-glucoside (6) were isolated from the stem bark of Pentas schimperi. Their structures were elucidated on the basis of spectroscopic analysis and comparison with published data or by comparison with authentic samples. To the best of our knowledge, it is the first report of cleomiscosin A, a coumarinolignan from the genus Pentas. Compound 2 exhibited in vitro cytotoxicity (IC50=33.05μM) against the human cancer cell the BGC-823. |
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ISSN: | 1874-3900 1876-7486 |
DOI: | 10.1016/j.phytol.2014.01.012 |