Synthetic strategies to prepare 2-alkyl, 2-aryl and 2-acetylenyl substituted 4,6-diamino-1,3,5-triazines

• Published in: Tetrahedron letters Vol. 47; no. 33; pp. 5973 - 5975
• Main Authors: Montalbetti, Christian A.G.N., Coulter, Thomas S., Uddin, Muhammed K., Reignier, Serge G., Magaraci, Filippo, Grånäs, Charlotta, Krog-Jensen, Christian, Felding, Jakob
• Format: Journal Article
• Language: English
• Published: OXFORD Elsevier Ltd 14.08.2006; Elsevier
• Subjects: Chemistry; Chemistry, Organic; FOXO1 Translocation; Nucleophilic substitution; Physical Sciences; PI3 Kinase pathway inhibitors; Science & Technology; Sonogashira; Suzuki; Triazine; Triazine; Sonogashira; PI3 Kinase pathway inhibitors; Nucleophilic substitution; Suzuki; FOXO1 Translocation; PALLADIUM; TRIAZINE LIBRARY; TUMOR-CELLS; CROSS-COUPLING REACTIONS; ORTHOGONAL SYNTHESIS; FOXO1 translocation; nucleophilic substitution; triazine; PI3 kinase pathway inhibitors; INHIBITORS; ANTAGONISTS; CHLORIDE

Strategies for introduction of malonyl, aryl or alkynyl substituents onto a triazine ring are described. We have developed synthetic protocols to generate 2-alkyl, 2-aryl and 2-acetylenyl substituted 4,6-diamino-1,3,5-triazines from the corresponding 2-chloro compound.