Synthetic strategies to prepare 2-alkyl, 2-aryl and 2-acetylenyl substituted 4,6-diamino-1,3,5-triazines

Strategies for introduction of malonyl, aryl or alkynyl substituents onto a triazine ring are described. We have developed synthetic protocols to generate 2-alkyl, 2-aryl and 2-acetylenyl substituted 4,6-diamino-1,3,5-triazines from the corresponding 2-chloro compound.

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Bibliographic Details
Published inTetrahedron letters Vol. 47; no. 33; pp. 5973 - 5975
Main Authors Montalbetti, Christian A.G.N., Coulter, Thomas S., Uddin, Muhammed K., Reignier, Serge G., Magaraci, Filippo, Grånäs, Charlotta, Krog-Jensen, Christian, Felding, Jakob
Format Journal Article
LanguageEnglish
Published OXFORD Elsevier Ltd 14.08.2006
Elsevier
Subjects
Chemistry
Chemistry, Organic
FOXO1 Translocation
Nucleophilic substitution
Physical Sciences
PI3 Kinase pathway inhibitors
Science & Technology
Sonogashira
Suzuki
Triazine
Triazine
Sonogashira
PI3 Kinase pathway inhibitors
Nucleophilic substitution
Suzuki
FOXO1 Translocation
PALLADIUM
TRIAZINE LIBRARY
TUMOR-CELLS
CROSS-COUPLING REACTIONS
ORTHOGONAL SYNTHESIS
FOXO1 translocation
nucleophilic substitution
triazine
PI3 kinase pathway inhibitors
INHIBITORS
ANTAGONISTS
CHLORIDE
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Summary:Strategies for introduction of malonyl, aryl or alkynyl substituents onto a triazine ring are described. We have developed synthetic protocols to generate 2-alkyl, 2-aryl and 2-acetylenyl substituted 4,6-diamino-1,3,5-triazines from the corresponding 2-chloro compound.
ISSN:0040-4039
1873-3581
DOI:10.1016/j.tetlet.2006.06.045