Synthetic strategies to prepare 2-alkyl, 2-aryl and 2-acetylenyl substituted 4,6-diamino-1,3,5-triazines
Strategies for introduction of malonyl, aryl or alkynyl substituents onto a triazine ring are described. We have developed synthetic protocols to generate 2-alkyl, 2-aryl and 2-acetylenyl substituted 4,6-diamino-1,3,5-triazines from the corresponding 2-chloro compound.
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| Published in | Tetrahedron letters Vol. 47; no. 33; pp. 5973 - 5975 |
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| Main Authors | , , , , , , , |
| Format | Journal Article |
| Language | English |
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OXFORD
Elsevier Ltd
14.08.2006
Elsevier |
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| Abstract | Strategies for introduction of malonyl, aryl or alkynyl substituents onto a triazine ring are described.
We have developed synthetic protocols to generate 2-alkyl, 2-aryl and 2-acetylenyl substituted 4,6-diamino-1,3,5-triazines from the corresponding 2-chloro compound. |
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| AbstractList | Strategies for introduction of malonyl, aryl or alkynyl substituents onto a triazine ring are described.
We have developed synthetic protocols to generate 2-alkyl, 2-aryl and 2-acetylenyl substituted 4,6-diamino-1,3,5-triazines from the corresponding 2-chloro compound. We have developed synthetic protocols to generate 2-alkyl, 2-aryl and 2-acetylenyl substituted 4,6-diamino-1,3,5-triazines from the corresponding 2-chloro compound. (c) 2006 Elsevier Ltd. All rights reserved. |
| Author | Krog-Jensen, Christian Felding, Jakob Magaraci, Filippo Coulter, Thomas S. Uddin, Muhammed K. Montalbetti, Christian A.G.N. Reignier, Serge G. Grånäs, Charlotta |
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| Issue | 33 |
| Keywords | Triazine Sonogashira PI3 Kinase pathway inhibitors Nucleophilic substitution Suzuki FOXO1 Translocation PALLADIUM TRIAZINE LIBRARY TUMOR-CELLS CROSS-COUPLING REACTIONS ORTHOGONAL SYNTHESIS FOXO1 translocation nucleophilic substitution triazine PI3 kinase pathway inhibitors INHIBITORS ANTAGONISTS CHLORIDE |
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| Snippet | Strategies for introduction of malonyl, aryl or alkynyl substituents onto a triazine ring are described.
We have developed synthetic protocols to generate... We have developed synthetic protocols to generate 2-alkyl, 2-aryl and 2-acetylenyl substituted 4,6-diamino-1,3,5-triazines from the corresponding 2-chloro... |
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| SubjectTerms | Chemistry Chemistry, Organic FOXO1 Translocation Nucleophilic substitution Physical Sciences PI3 Kinase pathway inhibitors Science & Technology Sonogashira Suzuki Triazine |
| Title | Synthetic strategies to prepare 2-alkyl, 2-aryl and 2-acetylenyl substituted 4,6-diamino-1,3,5-triazines |
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