Alginate functionalized magnetic-silica composites for pH-responsive drug delivery and magnetic hyperthermia applications
•Magnetic nanocomposites serve a significant function in the biomedical field.•Alginate is frequently used in drug delivery applications.•Magnetic hyperthermia is used to destroy cancer cells.•FeNP@SiOH@Alg for drug delivery and magnetic hyperthermia applications. A biopolymer sodium alginate (Alg)...
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Published in | Materials letters Vol. 361; p. 136088 |
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Main Authors | , , , , , , , , |
Format | Journal Article |
Language | English |
Published |
Elsevier B.V
15.04.2024
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Subjects | |
Online Access | Get full text |
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Summary: | •Magnetic nanocomposites serve a significant function in the biomedical field.•Alginate is frequently used in drug delivery applications.•Magnetic hyperthermia is used to destroy cancer cells.•FeNP@SiOH@Alg for drug delivery and magnetic hyperthermia applications.
A biopolymer sodium alginate (Alg) functionalized core–shell magnetic silica composite (FeNP@SiOH@Alg) has been proposed for pH-responsive drug delivery and magnetic hyperthermia applications. Various instruments such as XRD, FTIR, SEM, and TGA analysis were accessed to characterize the FeNP@SiOH@Alg. Under the alternating magnetic field (AMF), the magnetic hyperthermia and pH-responsive drug delivery efficiency of the prepared FeNP@SiOH@Alg were examined using doxorubicin (Dox) as a modal drug. Furthermore, the in vitro biocompatibility of the FeNP@SiOH@Alg on MDA-MB-231 cells was examined. All the findings indicated that FeNP@SiOH@Alg is effective for magnetic hyperthermia-based chemotherapy applications in cancer therapy. |
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ISSN: | 0167-577X 1873-4979 |
DOI: | 10.1016/j.matlet.2024.136088 |