Alginate functionalized magnetic-silica composites for pH-responsive drug delivery and magnetic hyperthermia applications

•Magnetic nanocomposites serve a significant function in the biomedical field.•Alginate is frequently used in drug delivery applications.•Magnetic hyperthermia is used to destroy cancer cells.•FeNP@SiOH@Alg for drug delivery and magnetic hyperthermia applications. A biopolymer sodium alginate (Alg)...

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Published inMaterials letters Vol. 361; p. 136088
Main Authors Mohan, Anandhu, Suresh, Ranganathan, Ashwini, Munusamy, Periyasami, Govindasami, Guganathan, Loganathan, Lin, Mei-Ching, Kumarasamy, Keerthika, Kim, Seong-Cheol, Santhamoorthy, Madhappan
Format Journal Article
LanguageEnglish
Published Elsevier B.V 15.04.2024
Subjects
Biocompatibility
Drug delivery
Magnetic hyperthermia
Magnetic NPs
Silica coating
Magnetic hyperthermia
Biocompatibility
Drug delivery
Silica coating
Magnetic NPs
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Summary:•Magnetic nanocomposites serve a significant function in the biomedical field.•Alginate is frequently used in drug delivery applications.•Magnetic hyperthermia is used to destroy cancer cells.•FeNP@SiOH@Alg for drug delivery and magnetic hyperthermia applications. A biopolymer sodium alginate (Alg) functionalized core–shell magnetic silica composite (FeNP@SiOH@Alg) has been proposed for pH-responsive drug delivery and magnetic hyperthermia applications. Various instruments such as XRD, FTIR, SEM, and TGA analysis were accessed to characterize the FeNP@SiOH@Alg. Under the alternating magnetic field (AMF), the magnetic hyperthermia and pH-responsive drug delivery efficiency of the prepared FeNP@SiOH@Alg were examined using doxorubicin (Dox) as a modal drug. Furthermore, the in vitro biocompatibility of the FeNP@SiOH@Alg on MDA-MB-231 cells was examined. All the findings indicated that FeNP@SiOH@Alg is effective for magnetic hyperthermia-based chemotherapy applications in cancer therapy.
ISSN:0167-577X
1873-4979
DOI:10.1016/j.matlet.2024.136088