Microwave-assisted efficient, one-pot, three-component synthesis of 3,5-disubstituted 1,2,4-oxadiazoles under solvent-free conditions

• Published in: Tetrahedron letters Vol. 47; no. 17; pp. 2965 - 2967
• Main Authors: Adib, Mehdi, Jahromi, Amin Haghighat, Tavoosi, Narjes, Mahdavi, Mohammad, Bijanzadeh, Hamid Reza
• Format: Journal Article
• Language: English
• Published: OXFORD Elsevier Ltd 24.04.2006; Elsevier
• Subjects: 1,2,4-Oxadiazoles; Aldehydes; Chemistry; Chemistry, Organic; Microwave irradiation; One-pot, three-component reaction; Physical Sciences; Science & Technology; Solvent-free synthesis; Microwave irradiation; 1,2,4-Oxadiazoles; Aldehydes; One-pot, three-component reaction; Solvent-free synthesis; one-pot; three-component reaction; IRRADIATION; aldehydes; 1,2,4-oxadiazoles; microwave irradiation; RECEPTOR; OXADIAZOLES; ANTAGONISTS; solvent-free synthesis

A novel synthesis of 1,2,4-oxadiazoles is described from a one-pot, three-component reaction between nitriles, hydroxylamine, and aldehydes under microwave irradiation and solvent-free conditions in excellent yields.