Microwave-assisted efficient, one-pot, three-component synthesis of 3,5-disubstituted 1,2,4-oxadiazoles under solvent-free conditions

A novel synthesis of 1,2,4-oxadiazoles is described from a one-pot, three-component reaction between nitriles, hydroxylamine, and aldehydes under microwave irradiation and solvent-free conditions in excellent yields.

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Bibliographic Details
Published inTetrahedron letters Vol. 47; no. 17; pp. 2965 - 2967
Main Authors Adib, Mehdi, Jahromi, Amin Haghighat, Tavoosi, Narjes, Mahdavi, Mohammad, Bijanzadeh, Hamid Reza
Format Journal Article
LanguageEnglish
Published OXFORD Elsevier Ltd 24.04.2006
Elsevier
Subjects
1,2,4-Oxadiazoles
Aldehydes
Chemistry
Chemistry, Organic
Microwave irradiation
One-pot, three-component reaction
Physical Sciences
Science & Technology
Solvent-free synthesis
Microwave irradiation
1,2,4-Oxadiazoles
Aldehydes
One-pot, three-component reaction
Solvent-free synthesis
one-pot
three-component reaction
IRRADIATION
aldehydes
1,2,4-oxadiazoles
microwave irradiation
RECEPTOR
OXADIAZOLES
ANTAGONISTS
solvent-free synthesis
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Summary:A novel synthesis of 1,2,4-oxadiazoles is described from a one-pot, three-component reaction between nitriles, hydroxylamine, and aldehydes under microwave irradiation and solvent-free conditions in excellent yields.
ISSN:0040-4039
1873-3581
DOI:10.1016/j.tetlet.2006.02.102