Electrochemical investigation of atenolol oxidation and detection by using a multicomponent nanostructural assembly of amino acids and gold nanoparticles

• Published in: Chemical physics letters Vol. 504; no. 1-3; pp. 56 - 61
• Main Authors: Pruneanu, Stela, Pogacean, Florina, Grosan, Camelia, Pica, Elena Maria, Bolundut, Liviu Calin, Biris, Alexandru Sorin
• Format: Journal Article
• Language: English
• Published: Elsevier B.V 28.02.2011
• ISSN: 0009-2614; 1873-4448
• DOI: 10.1016/j.cplett.2011.01.051

[Display omitted] ► Novel system based on poly(glutamic) acid/cysteine/Au nanoparticles was designed. ► This nanostructural system had excellent electrochemical behavior. ► Poly(glutamic) acid/cysteine/Au nanoparticles was used to study atenolol oxidation. ► Allows detection of atenolol oxidation peak with a limit of 3.9×10−7M. ► Excellent model for possible bio-chemical molecular detection. A novel nanostructured assembly based on poly(glutamic) acid/cysteine/gold nanoparticles was designed to modify the surface of a glassy carbon electrode (GCE) and used to study the atenolol oxidation. The GCE surface was initially covered by poly(glutamic) acid/cysteine layers followed by covalent attachment of citrate-capped 40nm-AuNPs. The system excellent electrochemical performance was tested by Linear Sweep Voltammetry and Electrochemical Impedance Spectroscopy and allowed the detection of an atenolol oxidation peak (around +0.65V/SCE) with a detection limit of 3.9×10−7M. Such findings could be incorporated in highly sensitive detection technologies of various biological or chemical compounds and molecules.