Marine Pharmacology in 2019-2021: Marine Compounds with Antibacterial, Antidiabetic, Antifungal, Anti-Inflammatory, Antiprotozoal, Antituberculosis and Antiviral Activities; Affecting the Immune and Nervous Systems, and Other Miscellaneous Mechanisms of Action

• Published in: Marine drugs Vol. 22; no. 7; p. 309
• Main Authors: Mayer, Alejandro M S, Mayer, Veronica A, Swanson-Mungerson, Michelle, Pierce, Marsha L, Rodríguez, Abimael D, Nakamura, Fumiaki, Taglialatela-Scafati, Orazio
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 30.06.2024
• Subjects: Algae; Animals; Anti-Bacterial Agents - chemistry; Anti-Bacterial Agents - pharmacology; Anti-Inflammatory Agents - chemistry; Anti-Inflammatory Agents - pharmacology; Antibiotics; Antidiabetics; Antifungal Agents - chemistry; Antifungal Agents - pharmacology; Antiinfectives and antibacterials; Antiparasitic agents; Antiprotozoal Agents - chemistry; Antiprotozoal Agents - pharmacology; Antitubercular Agents - chemistry; Antitubercular Agents - pharmacology; Antiviral activity; Antiviral agents; Antiviral Agents - chemistry; Antiviral Agents - pharmacology; Aquatic Organisms; Biofilms; Biological Products - chemistry; Biological Products - pharmacology; Chemokines; Diabetes mellitus; DNA damage; drug; E coli; Encephalitis; Fungi; Fungicides; Hepatitis C; HIV; Human immunodeficiency virus; Humans; Hypoglycemic Agents - chemistry; Hypoglycemic Agents - pharmacology; Immune System - drug effects; Inflammation; Literature reviews; Malaria; marine; Marine chemistry; Microorganisms; Natural products; Nervous system; Nervous System - drug effects; Peptides; pharmaceutical; Pharmacology; Proteins; Protozoa; review; sea; Staphylococcus infections; Tuberculosis; United States > US; pipeline; toxicology; pharmaceutical; preclinical; review; pharmacology; mechanism; marine; sea; drug
• ISSN: 1660-3397; 1660-3397
• DOI: 10.3390/md22070309

The current 2019-2021 marine pharmacology literature review provides a continuation of previous reviews covering the period 1998 to 2018. marine pharmacology research during 2019-2021 was published by researchers in 42 countries and contributed novel mechanism-of-action pharmacology for 171 structurally characterized marine compounds. The peer-reviewed marine natural product pharmacology literature reported antibacterial, antifungal, antiprotozoal, antituberculosis, and antiviral mechanism-of-action studies for 49 compounds, 87 compounds with antidiabetic and anti-inflammatory activities that also affected the immune and nervous system, while another group of 51 compounds demonstrated novel miscellaneous mechanisms of action, which upon further investigation, may contribute to several pharmacological classes. Thus, in 2019-2021, a very active marine natural product pharmacology pipeline provided novel mechanisms of action as well as new lead chemistry for the marine pharmaceutical pipeline targeting the therapy of several disease categories.