Design and synthesis of Schiff base Homobimetallic-Complexes as promising antimicrobial agents

• Published in: Inorganic chemistry communications Vol. 137; p. 109206
• Main Authors: Pervaiz, Muhammad, Sadiq, Amber, Sadiq, Sahar, Saeed, Zohaib, Imran, Muhammad, Younas, Umer, Majid Bukhari, Syed, Rashad Mahmood Khan, Rana, Rashid, Ayoub, Adnan, Ahmad
• Format: Journal Article
• Language: English
• Published: Elsevier B.V 01.03.2022
• Subjects: Anti-fungal activities; Bactericidal potential; Bio-potent metallo-drugs; Homobimetallic-complexes; Multidrug-resistant pathogens; Schiff bases; Anti-fungal activities; Multidrug-resistant pathogens; Homobimetallic-complexes; Schiff bases; Bactericidal potential; Bio-potent metallo-drugs
• ISSN: 1387-7003; 1879-0259
• DOI: 10.1016/j.inoche.2022.109206

The new synthesized bio-active Schiff bases have been coordinated with a variety of transition metals to design unique and potent homobimetallic-complexes. Further the antimicrobial action of the said compounds was screened and reported. The results advocated the complexes as prospective metallo-drug candidates against pathogens. Figure. The schematic synthesis of Schiff base derived homobimetallic-complexes and key to their antimicrobial action. [Display omitted] •The bio-potent Schiff bases construct distinctively stable transition-metal chelates.•Homobimetallic-complexes of Schiff bases have offered great deal of pharmacological applications against pathogens.•Binuclear metallic core exhibits double chelating effect in facilitating the penetration of these agents through microbial cell wall.•Screening of the remarkable antimicrobial potential of constructed homobimetallic-complexes. Multidrug-resistant pathogens such as MRSA (Methicillin-resistant Staphylococcus aureus) have challenged the potency of current antimicrobial drugs. The Schiff bases are weighed up as privileged bio-potent ligands in coordination chemistry afforded by the condensation of primary ammine and carbonyl functionalities. Extensive efforts have been done to fabricate the homobimetallic-complexes of Schiff bases finding their catalytic and biological utilities. These protean coordination compounds accredited with characteristic polydentate ligands, redox nature of metal centers and the geometry of complexes can afford remarkable structural tunability to reinvigorate their potential applications. During the last decade, homobimetallic-complexes have been the center of attention among pharmaceutical and medicinal chemists, owing to their significant microbicidal lineaments. The literature reports provided promising results for growth inhibitory response of binuclear metal (V, Cr, Mn, Fe, Co, Ni, Cu, Zn, Mo, Ru, Pd, Ag, Cd, Sn, W, Os, Hg, Pb) chelates of Schiff bases against a wide range of infectious bacteria and fungi. Herein we have compiled a comprehensive review, highlighting the schematic synthesis, characterization and antimicrobial screening of Schiff base derived homobimetallic-complexes which make them successful candidates for pharmacological investigations.