Synthesis, characterization, crystal structure and in vitro anticancer potentials of mono and bimetallic palladium(II)–N–heterocyclic carbene complexes

• Published in: Inorganic chemistry communications Vol. 75; pp. 41 - 45
• Main Authors: Ghdhayeb, Mohammed Z., Haque, Rosenani A., Budagumpi, Srinivasa, Khadeer Ahamed, Mohamed B., Majid, Amin Malik Shah Abdul
• Format: Journal Article
• Language: English
• Published: Elsevier B.V 01.01.2017
• Subjects: Anticancer activity; HCT116; MTT assay; Palladium–NHC complex; X–ray diffraction; HCT116; Palladium–NHC complex; MTT assay; X–ray diffraction; Anticancer activity
• ISSN: 1387-7003; 1879-0259
• DOI: 10.1016/j.inoche.2016.11.014

N–heterocyclic carbene (NHC) complexes of palladium(II) are generally active as catalysts toward various coupling reactions, while their pharmacological efficiencies are seldom explored. A new series of palladium(II) complexes of both, functionalized and non–functionalized NHCs that were active against the human colon cancer (HCT116) cells are reported. Complexes were prepared by the technique of transmetallation using palladium source and in situ prepared silver(I)–NHC complexes in acetonitrile, and all complexes are characterized using spectroscopic and analytical tools. Additionally, the structure of palladium complex 9 was elucidated using single crystal X–ray diffraction method. In vitro anticancer studies revealed that the palladium complexes, 9 and 10, having xylyl–spacers significantly inhibited the HCT116 cell growth, exhibiting IC50 values in low micromolar range in MTT assay. [Display omitted] •A series of Pd complexes are prepared.•Complexes are characterized by various methods.•Structure of complex 9 was studied by single crystal X-ray diffraction.•Anticancer activity of complexes was evaluated.