neo-Clerodane diterpenoids from Baccharis flabellata

• Published in: Phytochemistry (Oxford) Vol. 61; no. 4; pp. 389 - 394
• Main Authors: Juan Hikawczuk, Virginia E, Rossomando, Pedro C, Giordano, Oscar S, Saad, José Roberto
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier Ltd 01.10.2002; Elsevier
• Subjects: Asteraceae; Baccharis - chemistry; Baccharis flabellata; Biological and medical sciences; Chemical constitution; Diterpenes - chemistry; Diterpenes - isolation & purification; Diterpenoids; Fundamental and applied biological sciences. Psychology; Molecular Structure; neo-Clerodane-type; Plant Components, Aerial - chemistry; Plant physiology and development; Diterpenoids; neo-Clerodane-type; Baccharis flabellata; Asteraceae; Terpenoid; Molecular structure; Dicotyledones; Angiospermae; Diterpene; Isolation; Spermatophyta; Compositae
• ISSN: 0031-9422; 1873-3700
• DOI: 10.1016/S0031-9422(02)00241-8

Three diterpenoid derivatives were isolated from the acetone extract of Baccharis flabellata. Their structures were elucidated as 2,19;15,16-diepoxy- neo-clerodan-3,13(16),14-trien-18-oic acid, 15,16-epoxy-5,10- seco-clerodan-1(10),2,4,13(16),14-pentaen-18,19-olide and 15,16-epoxy- neo-clerodan-1,3,13(16),14-tetraen-18,19-olide through spectroscopic analyses. In the aerial parts of B. flabellata three neo-clerodane diterpenoids, 2,19;15,16-diepoxy- neo-clerodan-3,13(16),14-trien-18-oic acid, 15,16-epoxy-5,10- seco-clerodan-1(10),2,4,13(16),14-pentaen-18,19-olide and 15,16-epoxy- neo-clerodan-1,3,13(16),14-tetraen-18,19-olide, were isolated.