The Diagnostic Potential of Circulating Autoantibodies to Amyloid-β in Alzheimer's Disease

• Published in: Journal of Alzheimer's disease Vol. 94; no. 2; p. 537
• Main Authors: Xu, Guang-Yu, Liu, Yu-Hao, Zeng, Xiao-Qin, Chen, Dong-Wan, Zeng, Gui-Hua, Fan, Dong-Yu, Liu, Yu-Hui, Wang, Yan-Jiang
• Format: Journal Article
• Language: English
• Published: Netherlands 01.01.2023
• Subjects: amyloid-β; diagnosis; Alzheimer’s disease; autoantibodies; biomarkers
• ISSN: 1875-8908
• DOI: 10.3233/JAD-230252

The profile of naturally occurring antibodies to amyloid-β (NAbs-Aβ) is altered in patients with Alzheimer's disease (AD). However, the diagnostic potential of NAbs-Aβ for AD is not clear yet. This study aims to investigate the diagnostic capacities of NAbs-Aβ for AD. A total of 40 AD patients and 40 cognitively normal (CN) controls were enrolled in this study. Levels of NAbs-Aβ were detected by ELISA. The correlations of NAbs-Aβ levels with cognitive function and AD-associated biomarkers were examined by Spearman correlation analysis. Diagnostic abilities of NAbs-Aβ were evaluated by the receiver operating characteristic (ROC) curve analyses. The integrative diagnostic models were established by logistic regression models. We found that NAbs-Aβ7-18 had the highest diagnostic capability (AUC = 0.72) among all single NAbs-Aβ. The combined model (NAbs-Aβ7-18, NAbs-Aβ19-30, and NAbs-Aβ25-36) had a noticeable improvement (AUC = 0.84) in the diagnostic capacity compared with each single NAbs-Aβ. NAbs-Aβs are promising in the diagnosis of AD. Further investigations are needed to confirm the translational potential of this diagnostic strategy.