Injectable hyaluronic acid/oxidized chitosan hydrogels with hypochlorous acid released for instant disinfection and antibacterial effects

Bacterial infections of wounds significantly increase the occurrence of complications, which have become a public health problem and pose a serious threat to human health. Therefore, an ideal wound dressing should not only possess suitable mechanical strength and a moist environment, but also instan...

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Bibliographic Details
Published inFrontiers in materials Vol. 9
Main Authors Chen, Han, Liao, Ran, Du, Qianqian, Li, Cong, Xiao, Xiufeng, Shan, Yongqi
Format Journal Article
LanguageEnglish
Published Frontiers Media S.A 03.08.2022
Subjects
antibacterial effects
biocompatibility
hydrogel
hypochlorous acid
injectable
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Summary:Bacterial infections of wounds significantly increase the occurrence of complications, which have become a public health problem and pose a serious threat to human health. Therefore, an ideal wound dressing should not only possess suitable mechanical strength and a moist environment, but also instant disinfection and antibacterial properties. Owing to their high water content and permeability, hydrogels have great potential for the application in wound dressing. In this study, we developed an injectable hyaluronic acid (HA)/oxidized chitosan (OCS) hydrogel with good biocompatibility, self-healing, and tissue adhesive properties. Moreover, the slow release of micro hypochlorous acid (HClO), which is a common bactericide during hydrogel formation, can lead to instant disinfection; and the positive charge of OCS in this hydrogel can achieve a sustainable antibacterial effect. Thus, this hydrogel is a promising wound dressing material in clinical treatments.
ISSN:2296-8016
2296-8016
DOI:10.3389/fmats.2022.935096