Cytotoxic alkaloids from the fruits and seeds of Alangium salviifolium (L.f.) Wangerin

[Display omitted] •One new cephaeline-type alkaloid and one new natural product are reported.•These compounds enriched the structural phytochemistry of Alangium salviifolium (L.f.) Wangerin.•Seven compounds exhibited inhibitory effects against three human cancer cell lines. One new cepheline-type al...

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Published inPhytochemistry letters Vol. 26; pp. 195 - 198
Main Authors Zhou, Si-Yuan, Fan, Fengkai, Sun, Ji-Zheng, Guo, Ziyan, Sun, Wen-Ting, Chen, Ling, Tang, Qing-Qing, Qiu, Guofu, Yang, Sheng-Ping, Yu, Jianqing, Cai, You-Sheng
Format Journal Article
LanguageEnglish
Published Elsevier Ltd 01.08.2018
Subjects
Alangium salviifolium
Alkaloids
Cytotoxic activity
Alkaloids
Alangium salviifolium
Cytotoxic activity
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Summary:[Display omitted] •One new cephaeline-type alkaloid and one new natural product are reported.•These compounds enriched the structural phytochemistry of Alangium salviifolium (L.f.) Wangerin.•Seven compounds exhibited inhibitory effects against three human cancer cell lines. One new cepheline-type alkaloid 8-hydroxyl-cepheline (1) and one new natural product Δ1′,2′-deoxytubulosine (2), together with 9 known alkaloids have been isolated from the fruits and seeds of Alangium salviifolium (L.f.) Wangerin. The structures of the new alkaloids were elucidated by means of extensive spectroscopic analysis (2D NMR, HRESIMS). All alkaloids were evaluated for their cytotoxic activity against three human cancer cell lines, A-549, Hela and SKOV-3. Compounds 1-4, 6, 8 and 9 exhibited significant inhibitory effects against three human cancer cells with IC50 values (0.1–14 μM) comparable to those of cisplatin.
ISSN:1874-3900
1876-7486
DOI:10.1016/j.phytol.2018.06.012