A New Cytotoxic Compound from Methanol Extract of Koordersiodendron pinnatum Merr. Leaves

Chemical investigation of the methanol extract of Koordersiodendron pinnatum Merr. leaves resulted a new naphthalene derivative, (Z)-4-(tetradec-3-enyl)naphthalene-1,2,7-triol (1), together with three known compounds, b-sitosterol (2), 20-epibryonolic acid (3), and scopoletin (4). The structure of t...

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Bibliographic Details
Published inNatural product sciences Vol. 26; no. 4; pp. 279 - 320
Main Authors Fajriah, Sofa, Megawati, Megawati, Akhmad, Darmawan, Lotulung, Puspa Dewi N., Salahuddin, Salahuddin, Muhammad, Hanafi
Format Journal Article
LanguageEnglish
Published 한국생약학회 01.01.2020
Subjects
약학
Koordersiodendron pinnatum Merr
cytotoxic activities
P-388 murineleukemia cell lines
Naphthalene derivative
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Summary:Chemical investigation of the methanol extract of Koordersiodendron pinnatum Merr. leaves resulted a new naphthalene derivative, (Z)-4-(tetradec-3-enyl)naphthalene-1,2,7-triol (1), together with three known compounds, b-sitosterol (2), 20-epibryonolic acid (3), and scopoletin (4). The structure of the new compound was elucidated based on spectroscopic evidence. The isolated compounds (1-4) were tested their cytotoxic activities against the P-388 murine leukemia cell line and compound 1 has highest activity with IC50 1.94 mM. KCI Citation Count: 0
ISSN:1226-3907
2288-9027
DOI:10.20307/nps.2020.26.4.279