Three new 3,8-epoxy iridoids from the roots and rhizomes of Valeriana jatamansi

[Display omitted] •Three new iridoids, jatamanins V–X, were isolated from Valeriana jatamansi.•Jatamanins V and W were a pair of C-4 diastereomers.•All compounds were evaluated for their cytotoxic effects against glioma stem cells. Three new 3,8-epoxy iridoids, jatamanins V–X (1-3), and three known...

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Published inPhytochemistry letters Vol. 34; pp. 35 - 38
Main Authors Quan, Li-Qiu, Liu, Huan, Li, Rong-Tao, Li, Hong-Mei
Format Journal Article
LanguageEnglish
Published Elsevier Ltd 01.12.2019
Subjects
Cytotoxic activity
Glioma stem cells
Iridoids
Valeriana jatamansi
Valeriana jatamansi
Glioma stem cells
Iridoids
Cytotoxic activity
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Summary:[Display omitted] •Three new iridoids, jatamanins V–X, were isolated from Valeriana jatamansi.•Jatamanins V and W were a pair of C-4 diastereomers.•All compounds were evaluated for their cytotoxic effects against glioma stem cells. Three new 3,8-epoxy iridoids, jatamanins V–X (1-3), and three known ones (4-6), were obtained from the roots and rhizomes of Valeriana jatamansi. The structures of 1-3 were determined through their NMR and high-resolution mass spectroscopic analysis. Among them, compounds 1 and 2 were a pair of C-4 diastereomers. Additionally, all compounds were evaluated for their cytotoxic effects against glioma stem cells.
ISSN:1874-3900
1876-7486
DOI:10.1016/j.phytol.2019.09.007