Asperpentenone A, A novel polyketide isolated from the deep-sea derived fungus Aspergillus sp. SCSIO 41024

• Published in: Phytochemistry letters Vol. 35; pp. 99 - 102
• Main Authors: Chen, Weihao, Liu, Haiyi, Long, Jieyi, Tao, Huaming, Lin, Xiuping, Liao, Shengrong, Yang, Bin, Zhou, Xuefeng, Liu, Yonghong, Wang, Junfeng
• Format: Journal Article
• Language: English
• Published: Elsevier Ltd 01.02.2020
• Subjects: Antibacterial activity; Aspergillus; Deep-sea; Polyketide; Polyketide; Deep-sea; Aspergillus; Antibacterial activity
• ISSN: 1874-3900; 1876-7486
• DOI: 10.1016/j.phytol.2019.11.009

[Display omitted] •A novel polyketide was isolated from the deep-sea derived fungus Aspergillus sp. SCSIO 41024.•Extensive NMR spectroscopic analysis and X-ray crystallography data were used to elucidate the new structure.•Kojic acid (3) and griseofamine A (9) exhibited weak antibacterial activities. Asperpentenone A (1), a novel polyketide with a rare cyclopentenone-tetrahydrofuran moiety, was isolated along with eight known compounds (2–9) from the deep-sea derived fungus Aspergillus sp. SCSIO 41024. Their structures including absolute configurations were determined by extensive analysis of their spectroscopic analysis and X-ray crystallography. Biological evaluation results revealed that kojic acid (3) showed weak antibacterial activities against Bacillus thuringiensis and Acinetobacter baumannii with MIC values of 32 and 128 μg/mL, respectively. Furthermore, griseofamine A (9) exhibited weak antibacterial activity with an MIC value of 64 μg/mL against Escherichia coli. The results of antibacterial experiments and especially the large yield of kojic acid (3) indicated that kojic acid might represent a candidate precursor for the development of antimicrobial agents.