Nano-silver modified silica particles in antibacterial photodynamic therapy
•The growing number of drug-resistant bacteria is nowadays fundamental problem in health care system.•The antimicrobial photodynamic therapy can be enhanced by addition of Ag nanoparticles.•The nano Ag-Photolon represented a powerful antibacterial activity and photoactivity.•Lower Photolon concentra...
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Published in | Applied surface science Vol. 461; pp. 260 - 268 |
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Main Authors | , , , , , |
Format | Journal Article |
Language | English |
Published |
Elsevier B.V
15.12.2018
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Subjects | |
Online Access | Get full text |
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Summary: | •The growing number of drug-resistant bacteria is nowadays fundamental problem in health care system.•The antimicrobial photodynamic therapy can be enhanced by addition of Ag nanoparticles.•The nano Ag-Photolon represented a powerful antibacterial activity and photoactivity.•Lower Photolon concentration gives the same antibacterial effect in nano Ag’s presence.
Supporting role of silica nanospheres with surface modified by silver nanoparticles in antibacterial photodynamic therapy (APDT), was studied. Optical and antibacterial properties of a photosensitizer – Photolon® in the presence of silica based nanopowders doped with silver nanoparticles, were determined. Various concentrations of Photolon® solution and nanomaterials have been prepared in order to examine the optical absorption and the effectivity of antibacterial activity. It was found that the maximum optical absorption of Photolon® depends on its concentration and can be enhanced by the presence of silver nanoparticles. The presence of silver nanoparticles can thus lead to a reduction of the concentration of the photosensitizer while achieving the same level of antibacterial efficacy as in case of higher photosensitizer concentration without the presence of silver nanoparticles. Efficiency of APDT was enhanced by combination of nanosilver doped silica nanospheres, which have powerful antimicrobial and bactericidal activity and photoactive photosensitizer – Photolon®. |
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ISSN: | 0169-4332 1873-5584 |
DOI: | 10.1016/j.apsusc.2018.05.014 |